Human CFL2 Protein

<strong>Human CFL2 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011930_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CFL2, Cofilin-2 protein, CFL-2, CFL 2, NEM7 protein, CFL-2 protein, CFL 2 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Rosen SM, Joshi M, Hitt T, Beggs AH, Agrawal PB. Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype Hum Mol Genet. 2020 Jul 29;29(12):1996-2003._x000D_ 2: Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease Int Rev Neurobiol. 2019;148:169-230._x000D_ 3: Ogasawara M, Nishino I. A review of core myopathy: central core disease, multiminicore disease, dusty core disease, and core-rod myopathy Neuromuscul Disord. 2021 Oct;31(10):968-977._x000D_ 4: Thirion C, Stucka R, Mendel B, Gruhler A, Jaksch M, Nowak KJ, Binz N, Laing NG, Lochmüller H. Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle Eur J Biochem. 2001 Jun;268(12):3473-82._x000D_ 5: Nguyen MT, Min KH, Kim D, Park SY, Lee W. CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts Biochem Biophys Res Commun. 2020 Dec 17;533(4):710-716._x000D_ 6: Nguyen MT, Min KH, Lee W. Palmitic Acid-Induced miR-429-3p Impairs Myoblast Differentiation by Downregulating CFL2 Int J Mol Sci. 2021 Oct 11;22(20):10972._x000D_ 7: Papalouka V, Arvanitis DA, Vafiadaki E, Mavroidis M, Papadodima SA, Spiliopoulou CA, Kremastinos DT, Kranias EG, Sanoudou D. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle Mol Cell Biol. 2009 Nov;29(22):6046-58._x000D_ 8: Fattori F, Fiorillo C, Rodolico C, Tasca G, Verardo M, Bellacchio E, Pizzi S, Ciolfi A, Fagiolari G, Lupica A, Broda P, Pedemonte M, Moggio M, Bruno C, Tartaglia M, Bertini E, D'Amico A. Expanding the histopathological spectrum of CFL2-related myopathies Clin Genet. 2018 Jun;93(6):1234-1239._x000D_ 9: Agrawal PB, Greenleaf RS, Tomczak KK, Lehtokari VL, Wallgren-Pettersson C, Wallefeld W, Laing NG, Darras BT, Maciver SK, Dormitzer PR, Beggs AH. Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2 Am J Hum Genet. 2007 Jan;80(1):162-7._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34869336">10: Umer N, Arévalo L, Phadke S, Lohanadan K, Kirfel G, Sons D, Sofia D, Witke W, Schorle H. Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization Front Cell Dev Biol. 2021 Nov 4;9:749559. </a>_x000D_ _x000D_ <strong>Products Related to Human CFL2 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>