ZNF446 Antibody
Product Specifications
Background
ZNF446 contains a KRAB and three C (2) H (2) zinc fingers. ZNF446 is a transcription repressor when fused to GAL4 DNA-binding domain and co-transfected with VP-16. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1, suggesting that the ZNF446 protein may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions.
NCBI Gene ID
55663
Swiss Prot
Q9NWS9
Accession Number
NP_060378
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZNF446.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ZNF446 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=29-042
Calculated Molecular Weight
49 kDa
Applications Notes
ZNF446 antibody can be used for detection of ZNF446 by ELISA at 1:1562500. ZNF446 antibody can be used for detection of ZNF446 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ZNF446
NCBI Official Name
Zinc finger protein 446
NCBI Organism
Homo sapiens
Background Reference 01
Liu, F., et al., (2005) Biochem. Biophys. Res. Commun. 333 (1), 5-13.
Other Product Names
ZNF446, ZSCAN30, ZSCAN52, ZKSCAN20
Tested Applications
ELISA, WB
Protein ID
8923582
Physical Properties
Liquid
Curated Selection
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