ZBTB33 Antibody
Product Specifications
Background
ZBTB33 is a transcriptional regulator with bimodal DNA-binding specificity. ZBTB33 binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. ZBTB33 recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway. It may also activate transcription of a subset of target genes by the recruitment of CTNND2.
NCBI Gene ID
10009
Swiss Prot
Q86T24
Accession Number
NP_006768
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZBTB33.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ZBTB33 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=28-957
Calculated Molecular Weight
74 kDa
Applications Notes
ZBTB33 antibody can be used for detection of ZBTB33 by ELISA at 1:312500. ZBTB33 antibody can be used for detection of ZBTB33 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ZBTB33
NCBI Official Name
Zinc finger and BTB domain containing 33
NCBI Organism
Homo sapiens
Background Reference 01
Defossez, P.A., (2005) J. Biol. Chem. 280 (52), 43017-43023.
Other Product Names
ZBTB33, ZNF348, ZNF-kaiso
Tested Applications
ELISA, WB
Protein ID
5803229
Physical Properties
Liquid
Curated Selection
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