NR1H3 Antibody
Product Specifications
Background
Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.
NCBI Gene ID
10062
Swiss Prot
Q13133
Accession Number
NP_005684
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1H3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1H3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=28-915
Calculated Molecular Weight
50 kDa
Applications Notes
NR1H3 antibody can be used for detection of NR1H3 by ELISA at 1:1562500. NR1H3 antibody can be used for detection of NR1H3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NR1H3
NCBI Official Name
Nuclear receptor subfamily 1, group H, member 3
NCBI Organism
Homo sapiens
Background Reference 01
Albers, M., et al., (2006) J. Biol. Chem. 281 (8), 4920-4930.
Other Product Names
NR1H3, LXRA, LXR-a, RLD-1
Tested Applications
ELISA, WB
Protein ID
194294517
Physical Properties
Liquid
Curated Selection
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