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NR1H3 Antibody

Product Specifications

Background

Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.

NCBI Gene ID

10062

Swiss Prot

Q13133

Accession Number

NP_005684

Host

Rabbit

Reactivity

Human

Immunogen

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1H3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Transcription, Cancer, Signal Transduction

Purification

Antibody is purified by protein A chromatography method.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

Batch dependent

Buffer

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1H3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

Calculated Molecular Weight

50 kDa

Applications Notes

NR1H3 antibody can be used for detection of NR1H3 by ELISA at 1:1562500. NR1H3 antibody can be used for detection of NR1H3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Symbol

NR1H3

NCBI Official Name

Nuclear receptor subfamily 1, group H, member 3

NCBI Organism

Homo sapiens

Background Reference 01

Albers, M., et al., (2006) J. Biol. Chem. 281 (8), 4920-4930.

Other Product Names

NR1H3, LXRA, LXR-a, RLD-1

Tested Applications

ELISA, WB

Protein ID

194294517

Physical Properties

Liquid

Frequently Asked Questions

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