NR1D2 Antibody
Product Specifications
Background
NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
NCBI Gene ID
9975
Swiss Prot
Q14995
Accession Number
NP_005117
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1D2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1D2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=28-893
Calculated Molecular Weight
65 kDa
Applications Notes
NR1D2 antibody can be used for detection of NR1D2 by ELISA at 1:62500. NR1D2 antibody can be used for detection of NR1D2 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NR1D2
NCBI Official Name
Nuclear receptor subfamily 1, group D, member 2
NCBI Organism
Homo sapiens
Background Reference 01
Sauve, F., et al., (2001) Mol. Cell. Biol. 21 (1), 343-353.
Other Product Names
NR1D2, RVR, BD73, EAR-1R
Tested Applications
ELISA, WB
Protein ID
224177491
Physical Properties
Liquid
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