COPS2 Antibody
Product Specifications
Background
COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP. COPS2 is also innvolved in early stage of neuronal differentiation via its interaction with NIF3L1.
NCBI Gene ID
9318
Swiss Prot
P61203
Accession Number
NP_004227
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Zebrafish
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Tranfected 293T Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
51 kDa
Applications Notes
COPS2 antibody can be used for detection of COPS2 by ELISA at 1:312500. COPS2 antibody can be used for detection of COPS2 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
COPS2
NCBI Official Name
COP9 signalosome subunit 2
NCBI Organism
Homo sapiens
Background Reference 01
Moehren, U., (2004) (er) Nucleic Acids Res. 32 (10), 2995-3004.
Other Product Names
COPS2, ALIEN, CSN2, SGN2, TRIP15
Tested Applications
ELISA, WB, IHC
Protein ID
4759264
Physical Properties
Liquid
Frequently Asked Questions
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