ZFP36 Antibody
Product Specifications
Background
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
NCBI Gene ID
7538
Swiss Prot
P26651
Accession Number
NP_003398
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZFP36.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10410 - Fetal Lung Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ZFP36 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
34 kDa
Applications Notes
ZFP36 antibody can be used for detection of ZFP36 by ELISA at 1:312500. ZFP36 antibody can be used for detection of ZFP36 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ZFP36
NCBI Official Name
ZFP36 ring finger protein
NCBI Organism
Homo sapiens
Background Reference 01
Cao, H., et al., (2006) Biochem. J. 394 (PT 1), 285-297.
Other Product Names
ZFP36, TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A
Tested Applications
ELISA, WB
Protein ID
393539038
Physical Properties
Liquid
Curated Selection
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