NR1I3 Antibody
Product Specifications
Background
NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses.
NCBI Gene ID
12355
Swiss Prot
O35627
Accession Number
NP_033933
Host
Rabbit
Reactivity
Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of mouse NR1I3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1I3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
39 kDa
Applications Notes
NR1I3 antibody can be used for detection of NR1I3 by ELISA at 1:312500. NR1I3 antibody can be used for detection of NR1I3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NR1I3
NCBI Official Name
Nuclear receptor subfamily 1, group I, member 3
NCBI Organism
Mus musculus
Background Reference 01
Briancon, N. (2006) EMBO J. 25 (6), 1253-1262.
Other Product Names
NR1I3, CAR, MB67, Care2, ESTM32, AA209988, AI551208, CAR-beta
Tested Applications
ELISA, WB
Protein ID
83921568
Physical Properties
Liquid
Curated Selection
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