Pias2 Antibody
Product Specifications
Background
Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.
NCBI Gene ID
17344
Swiss Prot
Q8C5D8
Accession Number
AAB96678
Host
Rabbit
Reactivity
Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of mouse Pias2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store Pias2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=28-590
Calculated Molecular Weight
54 kDa
Applications Notes
Pias2 antibody can be used for detection of Pias2 by ELISA at 1:312500. Pias2 antibody can be used for detection of Pias2 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
Pias2
NCBI Official Name
Protein inhibitor of activated STAT 2
NCBI Organism
Mus musculus
Other Product Names
Pias2, 6330408K17Rik, AI462206, ARIP3, AU018068, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta, SIZ2
Tested Applications
ELISA, WB, IHC
Protein ID
2773148
Physical Properties
Liquid
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