THRB Antibody

THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store THRB antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

THRB antibody can be used for detection of THRB by ELISA at 1:1562500. THRB antibody can be used for detection of THRB by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.