P2RX7 Antibody
Product Specifications
Background
The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.
NCBI Gene ID
5027
Swiss Prot
Q4VKI1
Accession Number
Q4VKI1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human P2RX7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer , Inflammasomes
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store P2RX7 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
31 kDa
Applications Notes
P2RX7 antibody can be used for detection of P2RX7 by ELISA at 1:312500. P2RX7 antibody can be used for detection of P2RX7 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
P2RX7
NCBI Official Name
Purinergic receptor P2X, ligand-gated ion channel, 7
NCBI Organism
Homo sapiens
Background Reference 01
Buell, GN., et al., (1998) Receptors Channels 5 (6) :347-54.
Other Product Names
P2RX7, P2X7
Tested Applications
ELISA, WB, IHC
Protein ID
74753854
Physical Properties
Liquid
Frequently Asked Questions
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