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ACCN3 Antibody

Product Specifications

Background

ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.

NCBI Gene ID

9311

Swiss Prot

Q9UHC3

Accession Number

NP_004760

Host

Rabbit

Reactivity

Human

Immunogen

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ACCN3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Membrane, Signal Transduction

Purification

Antibody is purified by protein A chromatography method.

Positive Control

Cat. No. XBL-10408 - Fetal Kidney Tissue Lysate

Concentration

Batch dependent

Buffer

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ACCN3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

Calculated Molecular Weight

58 kDa

Applications Notes

ACCN3 antibody can be used for detection of ACCN3 by ELISA at 1:62500. ACCN3 antibody can be used for detection of ACCN3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Symbol

ASIC3

NCBI Official Name

Acid-sensing (proton-gated) ion channel 3

NCBI Organism

Homo sapiens

Background Reference 01

Jones, N.G., et al., (2004) J. Neurosci. 24 (48), 10974-9.

Other Product Names

ACCN3, ACCN3, TNaC1, DRASIC, SLNAC1

Tested Applications

ELISA, WB, IHC

Protein ID

4757710

Physical Properties

Liquid

Frequently Asked Questions

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