ACCN3 Antibody
Product Specifications
Background
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
NCBI Gene ID
9311
Swiss Prot
Q9UHC3
Accession Number
NP_004760
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ACCN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. XBL-10408 - Fetal Kidney Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ACCN3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
58 kDa
Applications Notes
ACCN3 antibody can be used for detection of ACCN3 by ELISA at 1:62500. ACCN3 antibody can be used for detection of ACCN3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ASIC3
NCBI Official Name
Acid-sensing (proton-gated) ion channel 3
NCBI Organism
Homo sapiens
Background Reference 01
Jones, N.G., et al., (2004) J. Neurosci. 24 (48), 10974-9.
Other Product Names
ACCN3, ACCN3, TNaC1, DRASIC, SLNAC1
Tested Applications
ELISA, WB, IHC
Protein ID
4757710
Physical Properties
Liquid
Curated Selection
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