Human Tyk2 Protein, His Tag (active enzyme)
Human Tyk2 Protein, His Tag (TY2-H5547) is expressed from Baculovirus-Insect cells. It contains AA Pro 871 - Cys 1187 (Accession # P29597-1) .
Product Specifications
Background
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3) . It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.5 kDa.
Accession Number
P29597-1
Expression Region
Pro 871 - Cys 1187
Host
Insect Cells
Target
Tyk2
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
38.5 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/TY2-H5547.pdf
Species
Human
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