TBX21 Antibody

TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG) . Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TBX21 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

TBX21 antibody can be used for detection of TBX21 by ELISA at 1:312500. TBX21 antibody can be used for detection of TBX21 by western blot at 1.0-2.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.