SIRT1 Antibody
Product Specifications
Background
SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.
NCBI Gene ID
23411
Swiss Prot
Q96EB6
Accession Number
NP_036370
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIRT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. XBL-10426 - Fetal Thymus Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SIRT1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
82 kDa
Applications Notes
SIRT1 antibody can be used for detection of SIRT1 by ELISA at 1:62500. SIRT1 antibody can be used for detection of SIRT1 by western blot at 5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SIRT1
NCBI Official Name
Sirtuin 1
NCBI Organism
Homo sapiens
Background Reference 01
Solomon, J.M., et al., (2006) Mol. Cell. Biol. 26 (1), 28-38.
Other Product Names
SIRT1, SIR2L1
Tested Applications
ELISA, WB
Protein ID
7657575
Physical Properties
Liquid
Frequently Asked Questions
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