TCF2 Antibody

Hepatocyte Nuclear Factor 1-. (HNF-1., Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5) . A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TCF2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

TCF2 antibody can be used for detection of TCF2 by ELISA at 1:62500. TCF2 antibody can be used for detection of TCF2 by western blot at 0.1-2.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.