SKIIP Antibody

SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly (A) -binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SKIIP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

SKIIP antibody can be used for detection of SKIIP by ELISA at 1:62500. SKIIP antibody can be used for detection of SKIIP by western blot at 1.0-5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.