CSEN Antibody
Product Specifications
Background
CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease.
NCBI Gene ID
30818
Swiss Prot
Q9Y2W7
Accession Number
NP_038462
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CSEN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CSEN antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=27-446
Calculated Molecular Weight
29 kDa
Applications Notes
CSEN antibody can be used for detection of CSEN by ELISA at 1:12500. CSEN antibody can be used for detection of CSEN by western blot at 2.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KCNIP3
NCBI Official Name
Kv channel interacting protein 3, calsenilin
NCBI Organism
Homo sapiens
Background Reference 01
Zaidi, N.F., et al., (2004) J. Neurochem. 89 (3), 593-601.
Other Product Names
CSEN, CSEN, DREAM, KCHIP3
Tested Applications
ELISA, WB, IHC
Protein ID
7305199
Physical Properties
Liquid
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