ESR2 Antibody

ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ESR2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

ESR2 antibody can be used for detection of ESR2 by ELISA at 1:12500. ESR2 antibody can be used for detection of ESR2 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.