SH3BP2 Antibody
Product Specifications
Background
SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism.
NCBI Gene ID
6452
Swiss Prot
P78314
Accession Number
NP_003014
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SH3BP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
721_B Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SH3BP2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
62 kDa
Applications Notes
SH3BP2 antibody can be used for detection of SH3BP2 by ELISA at 1:1562500. SH3BP2 antibody can be used for detection of SH3BP2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SH3BP2
NCBI Official Name
SH3-domain binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Idowu, B.D., (2008) Br J Oral Maxillofac Surg 46 (3), 229-230.
Other Product Names
SH3BP2, 3BP2, CRBM, CRPM, FLJ42079, RES4-23, 3BP-2
Tested Applications
ELISA, WB
Protein ID
170014703
Physical Properties
Liquid
Curated Selection
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