NKIRAS1 Antibody
Product Specifications
Background
NKIRAS1 is an atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. NKIRAS1 may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
NCBI Gene ID
28512
Swiss Prot
Q9NYS0
Accession Number
NP_065078
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NKIRAS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NKIRAS1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=27-004
Calculated Molecular Weight
22 kDa
Applications Notes
NKIRAS1 antibody can be used for detection of NKIRAS1 by ELISA at 1:62500. NKIRAS1 antibody can be used for detection of NKIRAS1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NKIRAS1
NCBI Official Name
NFKB inhibitor interacting Ras-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Adams, M.D., (er) Ann. Rheum. Dis. (2008) In press.
Other Product Names
NKIRAS1, KBRAS1, kappaB-Ras1
Tested Applications
ELISA, WB
Protein ID
9966809
Physical Properties
Liquid
Curated Selection
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