ITPK1 Antibody
Product Specifications
Background
ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. It probably acts as the rate-limiting enzyme of the InsP6 pathway. ITPK1 modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
NCBI Gene ID
3705
Swiss Prot
Q13572
Accession Number
NP_055031
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ITPK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10407 - Fetal Heart Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ITPK1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=26-957
Calculated Molecular Weight
45 kDa
Applications Notes
ITPK1 antibody can be used for detection of ITPK1 by ELISA at 1:312500. ITPK1 antibody can be used for detection of ITPK1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ITPK1
NCBI Official Name
Inositol-tetrakisphosphate 1-kinase
NCBI Organism
Homo sapiens
Background Reference 01
Chamberlain, P.P., (2007) J. Biol. Chem. 282 (38), 28117-28125.
Other Product Names
ITPK1, ITRPK1
Tested Applications
ELISA, WB
Protein ID
21359894
Physical Properties
Liquid
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