SIGIRR Antibody
Product Specifications
Background
SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
NCBI Gene ID
59307
Swiss Prot
Q6IA17
Accession Number
XP_001129013
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIGIRR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SIGIRR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=26-436
Calculated Molecular Weight
25 kDa
Applications Notes
SIGIRR antibody can be used for detection of SIGIRR by ELISA at 1:62500. SIGIRR antibody can be used for detection of SIGIRR by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SIGIRR
NCBI Official Name
Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
NCBI Organism
Homo sapiens
Other Product Names
SIGIRR, MGC110992, TIR8
Tested Applications
ELISA, WB
Protein ID
113422713
Physical Properties
Liquid
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