SLC5A5 Antibody
Product Specifications
Background
The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones.The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones (Dohan et al., 2007 [PubMed 18077370]) .
NCBI Gene ID
6528
Swiss Prot
Q92911
Accession Number
NP_000444
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SLC5A5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
293T Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SLC5A5 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
69 kDa
Applications Notes
SLC5A5 antibody can be used for detection of SLC5A5 by ELISA at 1:1562500. SLC5A5 antibody can be used for detection of SLC5A5 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SLC5A5
NCBI Official Name
Solute carrier family 5 (sodium/iodide cotransporter), member 5
NCBI Organism
Homo sapiens
Background Reference 01
Fenton, M.S., (2008) Endocrinology 149 (5), 2592-2606.
Other Product Names
SLC5A5, NIS, TDH1
Tested Applications
ELISA, WB
Protein ID
4507035
Physical Properties
Liquid
Curated Selection
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