MARCH2 Antibody
Product Specifications
Background
MARCH2 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH2 may be involved in endosomal trafficking through interaction with STX6.
NCBI Gene ID
51257
Swiss Prot
Q9P0N8
Accession Number
NP_001005415
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MARCH2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MARCH2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=25-810
Calculated Molecular Weight
27 kDa
Applications Notes
MARCH2 antibody can be used for detection of 40239 by ELISA at 1:312500. MARCH2 antibody can be used for detection of 40239 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MARCH2
NCBI Official Name
Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Cao, Z., (2008) Cell. Signal. 20 (1), 73-82.
Other Product Names
MARCH2, HSPC240, MARCH-II, RNF172
Tested Applications
ELISA, WB
Protein ID
53729332
Physical Properties
Liquid
Curated Selection
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