PPP4R2 Antibody
Product Specifications
Background
PPP4R2 is the regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . It may regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
NCBI Gene ID
151987
Swiss Prot
Q9NY27
Accession Number
NP_777567
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPP4R2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PPP4R2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=25-799
Calculated Molecular Weight
47 kDa
Applications Notes
PPP4R2 antibody can be used for detection of PPP4R2 by ELISA at 1:62500. PPP4R2 antibody can be used for detection of PPP4R2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PPP4R2
NCBI Official Name
Protein phosphatase 4, regulatory subunit 2
NCBI Organism
Homo sapiens
Background Reference 01
Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007) .
Other Product Names
PPP4R2, MGC131930, PP4R2
Tested Applications
ELISA, WB
Protein ID
28372531
Physical Properties
Liquid
Curated Selection
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