DNASE2B Antibody
Product Specifications
Background
DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this protein is restricted to the salivary gland and lungs. The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
NCBI Gene ID
58511
Swiss Prot
Q8WZ79
Accession Number
NP_067056
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DNASE2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DNASE2B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=25-784
Calculated Molecular Weight
39 kDa
Applications Notes
DNASE2B antibody can be used for detection of DNASE2B by ELISA at 1:1562500. DNASE2B antibody can be used for detection of DNASE2B by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
DNASE2B
NCBI Official Name
Deoxyribonuclease II beta
NCBI Organism
Homo sapiens
Background Reference 01
Nishimoto, S., (2003) Nature 424 (6952), 1071-1074.
Other Product Names
DNASE2B, DLAD
Tested Applications
ELISA, WB
Protein ID
194473657
Physical Properties
Liquid
Curated Selection
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