PABPC1 Antibody
Product Specifications
Background
The poly (A) -binding protein (PABP), which is found complexed to the 3-prime poly (A) tail of eukaryotic mRNA, is required for poly (A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680) . In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.The poly (A) -binding protein (PABP), which is found complexed to the 3-prime poly (A) tail of eukaryotic mRNA, is required for poly (A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680) . In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.
NCBI Gene ID
26986
Swiss Prot
P11940
Accession Number
NP_002559
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PABPC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PABPC1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
71 kDa
Applications Notes
PABPC1 antibody can be used for detection of PABPC1 by ELISA at 1:1562500. PABPC1 antibody can be used for detection of PABPC1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PABPC1
NCBI Official Name
Poly (A) binding protein, cytoplasmic 1
NCBI Organism
Homo sapiens
Background Reference 01
Rivera, C.I. (2008) Virology 375 (1), 59-72.
Other Product Names
PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1
Tested Applications
ELISA, WB
Protein ID
46367787
Physical Properties
Liquid
Curated Selection
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