NR1H3 Antibody
Product Specifications
Background
Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.
NCBI Gene ID
10062
Swiss Prot
Q13133
Accession Number
NP_005684
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1H3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1H3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
50 kDa
Applications Notes
NR1H3 antibody can be used for detection of NR1H3 by ELISA at 1:62500. NR1H3 antibody can be used for detection of NR1H3 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NR1H3
NCBI Official Name
Nuclear receptor subfamily 1, group H, member 3
NCBI Organism
Homo sapiens
Background Reference 01
Torra, I.P., (2008) Mol. Cell. Biol. 28 (8), 2626-2636.
Other Product Names
NR1H3, LXR-a, LXRA, RLD-1
Tested Applications
ELISA, WB
Protein ID
194294517
Physical Properties
Liquid
Frequently Asked Questions
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