COPS2 Antibody
Product Specifications
Background
COPS2 is an essential component of the COP9 signalosome complex (CSN) . The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
NCBI Gene ID
9318
Swiss Prot
P61201
Accession Number
NP_004227
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=25-187
Calculated Molecular Weight
52 kDa
Applications Notes
COPS2 antibody can be used for detection of COPS2 by ELISA at 1:2500. COPS2 antibody can be used for detection of COPS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
COPS2
NCBI Official Name
COP9 signalosome subunit 2
NCBI Organism
Homo sapiens
Background Reference 01
Leal, J.F., (2008) Oncogene 27 (14), 1961-1970.
Other Product Names
COPS2, ALIEN, CSN2, SGN2, TRIP15
Tested Applications
ELISA, WB
Protein ID
4759264
Physical Properties
Liquid
Curated Selection
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