TCF7L1 Antibody
Product Specifications
Background
TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
NCBI Gene ID
83439
Swiss Prot
Q9HCS4
Accession Number
NP_112573
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TCF7L1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
293T Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TCF7L1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
63 kDa
Applications Notes
TCF7L1 antibody can be used for detection of TCF7L1 by ELISA at 1:312500. TCF7L1 antibody can be used for detection of TCF7L1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
TCF7L1
NCBI Official Name
Transcription factor 7-like 1 (T-cell specific, HMG-box)
NCBI Organism
Homo sapiens
Background Reference 01
Hillier, L.W., (2005) Nature 434 (7034), 724-731.
Other Product Names
TCF7L1, TCF-3, TCF3
Tested Applications
ELISA, WB
Protein ID
13786123
Physical Properties
Liquid
Curated Selection
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