GITR Antibody [DTA-1], Rabbit IgG
Product Specifications
Other Statements
This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
NCBI Gene ID
21936
Swiss Prot
O35714
Reactivity
Mouse
Immunogen
This antibody was raised by immunising Wistar rats with the CD25+CD4+ T cell line. Hybridoma cells were generated by fusing spleen cells from the immunized rat with P3X63Ag8.653 myeloma cells, assessed for secreting antibodies capable of neutralizing in vitro CD25+CD4+ T cell-mediated suppression of anti-CD3-stimulated T cell proliferation9, and then cloned. This DTA-1 clone secreted a monoclonal rat immunoglobulin G2a (IgG2a) that showed high neutralizing activity.
Clonality
Recombinant Monoclonal
Clone
DTA-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Cancer
Concentration
Batch dependent
Buffer
PBS with 0.02% Proclin 300.
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Fragment
IgG lambda
Symbol
Tnfrsf18
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 18
NCBI Organism
Mus musculus
Other Product Names
CD357, AITR, GITR-D, Glucocorticoid-induced TNFR-related protein, TNFRSF18, Tumor necrosis factor receptor superfamily member 18
Tested Applications
Flow, WB, IP, Agonism
Species
Rabbit
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