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SARS-COV-2 Nucleocapsid Protein Antibody [3E8A5]

Product Specifications

Background

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

NCBI Gene ID

1489678

Swiss Prot

P0DTC9

Accession Number

QHD43423.2

Host

Rabbit

Reactivity

Virus

Immunogen

E.coli derived SARS-COV-2 Nucleoproteins Ser2-Ala419 (Gly335Ala) Accession #QHD43423.2

Clonality

Recombinant Monoclonal

Clone

3E8A5

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Concentration

1 mg/ml

Buffer

Lyophilized from a 0.2 um filtered solution in PBS, pH7.4

Modification

NONE

Shipping Conditions

Room Temp

Storage Conditions

2˚ C - 8˚ C for one month, -20˚ C to -80˚ C for one year. Avoid repeated freeze-thaw cycles

Fragment

Rabbit IgG

Specificity

SARS-COV-2

Applications Notes

ELISA Capture: Recommended Concentration:0.5-2ug/mL, Sample: SARS-CoV-2 Nucleocapsid Protein Antibody (CAP) ELISA Capture: Recommended Concentration:0.005-0.02ug/mL, Sample: SARS-CoV-2 Nucleocapsid Protein Antibody Standard:Recommended Concentration: 7.8-500pg/mL, Sample: Recombinant SARS-COV-2 Nucleocapsid Protein with His tag

Symbol

N

NCBI Official Name

Nucleocapsid phosphoprotein

NCBI Organism

SARS-CoV-2

Other Product Names

SARS-CoV-2 Nucleocapsid Protein, SARS-CoV-2 NP, nucleocapsid protein [Severe acute respiratory syndrome coronavirus 2], novel coronavirus N Protein, novel coronavirus Nucleocapsid Protein, 2019-nCoV Nucleoprotein, 2019-nCoV N, 2019nCoV N, 2019-nCoV N Protein, 2019 peak N Protein, 2019-nCoV nucleocapsid protein.

Tested Applications

ELISA

Physical Properties

Lyophilized

Curated Selection

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