NSD1 Antibody
Product Specifications
Background
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
NCBI Gene ID
64324
Swiss Prot
Q96L73
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human NSD1 (NP_071900.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=24-011
Calculated Molecular Weight
Observed: 297kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:1000
Symbol
NSD1
Positive Control 2
A-549
Positive Control 3
MCF7
Positive Control 4
SW480
Positive Control 5
Mouse kidney
Positive Control 6
Mouse lung
NCBI Official Name
Nuclear receptor binding SET domain protein 1
NCBI Organism
Homo sapiens
Other Product Names
ARA267, KMT3B, SOTOS, SOTOS1, STO, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, H3-K36-HMTase, H4-K20-HMTase, NR-binding SET domain-containing protein, androgen receptor coactivator 267 kDa protein, androgen receptor-associated coregulator 267, androgen receptor-associated protein of 267 kDa, lysine N-methyltransferase 3B, nuclear receptor SET domain-containing protein 1, nuclear receptor-binding SET domain-containing protein 1, truncated nuclear receptor binding SET domain protein 1
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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