FBLN5 Antibody

Product Specifications

Background

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3) .

NCBI Gene ID

10516

Swiss Prot

Q9UBX5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

SKOV3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 72kDa

Fragment

IgG

Symbol

FBLN5

Positive Control 2

HT-29

Positive Control 3

293T

Positive Control 4

A-549

Positive Control 5

A375

Positive Control 6

Mouse kidney

NCBI Official Name

Fibulin 5

NCBI Organism

Homo sapiens

Other Product Names

FBLN5, fibulin 5, ARMD3, DANCE, EVEC, FLJ90059, UP50, developmental arteries and neural crest epidermal growth factor-like, urine p50 protein, UNQ184/PRO210