NODAL Antibody
Product Specifications
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.
NCBI Gene ID
4838
Swiss Prot
Q96S42
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 198-347 of human NODAL (NP_060525.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Stem Cell
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 44kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
NODAL
Positive Control 2
HepG2
Positive Control 3
293T
Positive Control 4
Rat liver
NCBI Official Name
Nodal growth differentiation factor
NCBI Organism
Homo sapiens
Other Product Names
NODAL, nodal homolog (mouse), MGC138230, mouse nodal homolog precursor, nodal, mouse, homolog, HTX5
Tested Applications
WB
Physical Properties
Liquid
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