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RASA4 Antibody

Product Specifications

Background

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca (2+) . Stimuli that increase intracellular Ca (2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

10156

Swiss Prot

O43374

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

Affinity purification

Positive Control

SH-SY5Y

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=23-946

Calculated Molecular Weight

Observed: 100kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

RASA4

Positive Control 2

293T

Positive Control 3

Mouse thymus

Positive Control 4

Mouse spleen

NCBI Official Name

RAS p21 protein activator 4

NCBI Organism

Homo sapiens

Other Product Names

CAPRI, GAPL, ras GTPase-activating protein 4, Ca2+-promoted Ras inactivator, calcium-promoted Ras inactivator, rasGAP-activating-like protein 2

Tested Applications

WB

Physical Properties

Liquid

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