RASA4 Antibody
Product Specifications
Background
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca (2+) . Stimuli that increase intracellular Ca (2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
10156
Swiss Prot
O43374
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 100kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
RASA4
Positive Control 2
293T
Positive Control 3
Mouse thymus
Positive Control 4
Mouse spleen
NCBI Official Name
RAS p21 protein activator 4
NCBI Organism
Homo sapiens
Other Product Names
CAPRI, GAPL, ras GTPase-activating protein 4, Ca2+-promoted Ras inactivator, calcium-promoted Ras inactivator, rasGAP-activating-like protein 2
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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