RPE65 Antibody
Product Specifications
Background
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.
NCBI Gene ID
6121
Swiss Prot
Q16518
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
U-251MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=23-937
Calculated Molecular Weight
Observed: 61kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
RPE65
Positive Control 2
NCI-H460
Positive Control 3
THP-1
Positive Control 4
HeLa
Positive Control 5
Mouse heart
Positive Control 6
Mouse brain
NCBI Official Name
Retinal pigment epithelium-specific protein 65kDa
NCBI Organism
Homo sapiens
Other Product Names
Retinal pigment epithelium-specific protein 65 kDa, LCA2, RP20, mRPE65, rd12, sRPE65, RBP-binding membrane protein, p63, retinal pigment epithelium-specific 61 kDa protein, retinal pigment epithelium-specific protein (65kD), retinitis pigmentosa 20
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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