ADH-503

ADH-503 ((Z) -Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].

Product Specifications

CAS Number

[2055362-74-6]

Product Name Alternative

(Z) -Leukadherin-1 (choline)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adh-503.html

Purity

98.04

Solubility

DMSO : 21.43 mg/mL (ultrasonic) |Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 100 mg/mL (ultrasonic)

Smiles

O=C([O-])C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1.OCC[N+](C)(C)C

Molecular Formula

C27H28N2O5S2

Molecular Weight

524.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11 (499) .