CYP46A1 Antibody
Product Specifications
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
NCBI Gene ID
10858
Swiss Prot
Q9Y6A2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 57kDa
Fragment
IgG
Symbol
CYP46A1
Positive Control 2
U-251MG
Positive Control 3
MCF7
Positive Control 4
Mouse liver
Positive Control 5
Mouse brain
Positive Control 6
Rat liver
NCBI Official Name
Cytochrome P450, family 46, subfamily A, polypeptide 1
NCBI Organism
Homo sapiens
Other Product Names
CYP46A1, CP46, CYP46
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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