CKAP5 Antibody

Product Specifications

Background

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

9793

Swiss Prot

Q14008

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1763-2032 of human CKAP5 (NP_001008938.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 250kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

CKAP5

Positive Control 2

Jurkat

Positive Control 3

HepG2

Positive Control 4

HT-29

Positive Control 5

Mouse brain

Positive Control 6

Mouse lung

NCBI Official Name

Cytoskeleton associated protein 5

NCBI Organism

Homo sapiens

Other Product Names

CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton-associated protein 5, colonic and hepatic tumor over-expressed gene protein, colonic and hepatic tumor overexpressed gene protein