PIK3C2A Antibody
Product Specifications
Background
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
NCBI Gene ID
5286
Swiss Prot
O00443
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIK3C2A (NP_002636.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Autophagy, Cell Cycle, Immunology, Innate Immunity, Signal Transduction
Purification
Affinity purification
Positive Control
SKOV3
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=23-640
Calculated Molecular Weight
Observed: 191kDa
Fragment
IgG
Symbol
PIK3C2A
Positive Control 2
HepG2
NCBI Official Name
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
NCBI Organism
Homo sapiens
Other Product Names
PIK3C2A, CPK, PI3-K-C2A, PI3K-C2alpha, PI3-K-C2 (ALPHA), phosphoinositide-3-kinase, class 2, alpha polypeptide, C2-containing phosphatidylinositol kinase
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid
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