PIK3C2A Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

NCBI Gene ID

5286

Swiss Prot

O00443

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIK3C2A (NP_002636.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Autophagy, Cell Cycle, Immunology, Innate Immunity, Signal Transduction

Purification

Affinity purification

Positive Control

SKOV3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 191kDa

Fragment

IgG

Symbol

PIK3C2A

Positive Control 2

HepG2

NCBI Official Name

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

NCBI Organism

Homo sapiens

Other Product Names

PIK3C2A, CPK, PI3-K-C2A, PI3K-C2alpha, PI3-K-C2 (ALPHA), phosphoinositide-3-kinase, class 2, alpha polypeptide, C2-containing phosphatidylinositol kinase