RNF34 Antibody
Product Specifications
Background
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
80196
Swiss Prot
Q969K3
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RNF34 (NP_079402.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle
Purification
Affinity purification
Positive Control
U-251MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 42kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
RNF34
Positive Control 2
LO2
Positive Control 3
HeLa
Positive Control 4
BT-474
NCBI Official Name
Ring finger protein 34, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Other Product Names
RNF34, ring finger protein 34, RFI, RIF, RIFF, FLJ21786, RING finger protein RIFF, FYVE-RING finger protein MOMO, hRFI, CARP1, CARP-1
Tested Applications
WB
Physical Properties
Liquid
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