MAP3K12 Antibody
Product Specifications
Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
NCBI Gene ID
7786
Swiss Prot
Q12852
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human MAP3K12 (NP_001180440.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=23-601
Calculated Molecular Weight
Observed: 120kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
MAP3K12
Positive Control 2
HT-1080
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 12
NCBI Organism
Homo sapiens
Other Product Names
DLK, MEKK12, MUK, ZPK, ZPKP1, mitogen-activated protein kinase kinase kinase 12, MAPK-upstream kinase, dual leucine zipper bearing kinase, dual leucine zipper kinase DLK, leucine zipper protein kinase, mixed lineage kinase, protein kinase MUK
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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