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NRGN Antibody

Product Specifications

Background

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

NCBI Gene ID

4900

Swiss Prot

Q92686

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human NRGN (NP_001119653.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

PC-3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=23-588

Calculated Molecular Weight

Observed: 14kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

NRGN

Positive Control 2

U-251MG

Positive Control 3

HeLa

NCBI Official Name

Neurogranin (protein kinase C substrate, RC3)

NCBI Organism

Homo sapiens

Other Product Names

Neurogranin, protein kinase C substrate, neurogranin, calmodulin-binding protein, hng, RC3, neurogranin (protein kinase C substrate, RC3), NRGN

Tested Applications

WB

Physical Properties

Liquid

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