NRGN Antibody
Product Specifications
Background
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
NCBI Gene ID
4900
Swiss Prot
Q92686
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human NRGN (NP_001119653.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
PC-3
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 14kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
NRGN
Positive Control 2
U-251MG
Positive Control 3
HeLa
NCBI Official Name
Neurogranin (protein kinase C substrate, RC3)
NCBI Organism
Homo sapiens
Other Product Names
Neurogranin, protein kinase C substrate, neurogranin, calmodulin-binding protein, hng, RC3, neurogranin (protein kinase C substrate, RC3), NRGN
Tested Applications
WB
Physical Properties
Liquid
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