DROSHA Antibody
Product Specifications
Background
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
NCBI Gene ID
29102
Swiss Prot
Q9NRR4
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DROSHA (NP_037367.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 180kDa
Fragment
IgG
Symbol
DROSHA
NCBI Official Name
Drosha, ribonuclease type III
NCBI Organism
Homo sapiens
Other Product Names
Rnasen, ribonuclease III, nuclear, 1110013A17Rik, AI874853, Etohi2, MGC115770, Rn3, ethanol induced 2, Drosha, RN3, RNASE3L, RNASEN
Tested Applications
WB, IF
Physical Properties
Liquid
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