SOST Antibody
Product Specifications
Background
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
NCBI Gene ID
50964
Swiss Prot
Q9BQB4
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 30kDa
Fragment
IgG
Symbol
SOST
Positive Control 2
HepG2
NCBI Official Name
Sclerostin
NCBI Organism
Homo sapiens
Other Product Names
SOST, sclerosteosis, VBCH, sclerostin
Tested Applications
WB, IHC
Physical Properties
Liquid
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