POR Antibody, KO Validated
Product Specifications
Background
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
NCBI Gene ID
5447
Swiss Prot
P16435
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human POR (NP_000932.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
A-549
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 77kDa
Fragment
IgG
Symbol
POR
Positive Control 2
HeLa
Positive Control 3
MCF-7
Positive Control 4
293T
Positive Control 5
Mouse liver
Positive Control 6
Mouse skin
NCBI Official Name
P450 (cytochrome) oxidoreductase
NCBI Organism
Homo sapiens
Other Product Names
POR, CPR, CYPOR, DKFZp686G04235, FLJ26468, P450R
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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